Soon-Gook Hong, PhD
Postdoc
About
Soon-Gook is a Postdoctoral Fellow in the Mack Lab in the Department of Medicine, Division of Cardiology at UCLA. He holds a BA in Physical Education from Korea University and MS in Exercise Physiology from Seoul National University in South Korea. During his time as a MS student, Soon-Gook participated in multiple human research projects focusing on the effects of physical activity on chronic diseases associated with aging and cognitive function in elderly. Then, he worked in Dr. Joon Park’s Laboratory in the Cardiovascular Research Center, Lewis Katz School of Medicine, Temple University as a Research Assistant during his doctoral study where he received his Ph.D. in Kinesiology: Integrative Exercise Physiology focusing on mitochondrial dynamics and mitophagy process in endothelial cells under physiological flow conditions. His postdoctoral research focuses on mechanisms of endothelial cell resilience under flow in endothelial cells with the focus on vascular disease prevention. His research areas of interest include endothelial biology, mechanobiology, mitochondrial biology, and exercise physiology. The long-term goal of his research is to elucidate the molecular signaling mechanisms by which blood flow regulates endothelial cell function and how physical activity improves adverse effects of aging, especially in the blood vessel. During his spare time, Soon-Gook enjoys outdoor activities, including playing golf, hiking, fishing, swimming, and weight training.
Publications
- Soon-Gook Hong, Julianne W. Ashby, John P. Kennelly, Eesha Chattopadhyay, Rob Foreman, Peter Tontonoz, Patric Turowski, Marcus Gallagher-Jones and Julia J. Mack. (2024). Mechanosensitive Membrane Domains Regulate Calcium Entry in Arterial Endothelial Cells to Protect Against Inflammation. The Journal of Clinical Investigation, 134(13):e175057. https://doi.org/10.1172/JCI175057(IF: 15.9)
- Soon-Gook Hong, John P. Kennelly, Kevin J. Williams, Steve J. Bensinger and Julia J. Mack. (2024). Flow-mediated Modulation of the Endothelial Cell Lipidome. Frontiers in Physiology,50-2024; doi: 10.3389/fphys.2024.1431847 (IF: 3.394)
- Soon-Gook Hong, Junchul Shin, Soo Young Choi, Jeffery C. Powers, Benjamin M. Meister, Jacqueline Sayoc, Jun Seok Son, Ryan Tierney, Fabio A. Recchia, Michael D. Brown, Xiaofeng Yang, and Joon-Young Park. (2022). Flow pattern-dependent mitochondrial dynamics regulates metabolic profile and inflammatory state of endothelial cells. JCI Insight, 7(18):e159286. (IF:9.484)
- Junchul Shin1, Soon-Gook Hong1, Soo Young Choi, Meghan E. Rath, Jason Saredy, Daniel G. Jovin, Hye-Sang Park, Satoru Eguchi, Victor Rizzo, Rosario Scalia, Hong Wang, Steven R. Houser, Joon-Young Park. (2022). Flow-induced Endothelial Mitochondrial Remodeling Mitigates Mitochondrial Reactive Oxygen Species Production and Promotes Mitochondrial DNA Integrity in a p53-dependent manner. Redox Biology, 50:2213-2317. (IF: 11.8) 1co-first authors